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Phoenix (602) 269-5914

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Our team of dental specialists and staff strive to improve the overall health of our patients by focusing on preventing, diagnosing and treating conditions associated with your teeth and gums. Please use our dental library to learn more about dental problems and treatments available. If you have questions or need to schedule an appointment, contact us.
 

Bacterial Link Between Heart Disease and Gum Disease Clarified 
September 30th, 2015 By Managing Editor, DiabetesinControl.com 

A study, published in Infection and Immunity, has clarified the mechanism behind a known link between gum disease and heart disease. Periodontitis, which results in an infection that damages the soft-tissue surrounding teeth and the bone supporting the teeth, is commonly caused by Porphyromonas gingivalis. P. gingivalis is a Gram-negative anaerobe that colonizes mouth tissues for lengthy periods of time after initial infection. It is commonly found within the arterial plaques common to heart disease patients. 

The study authors discovered that the bacteria alters the gene expression of pro-inflammatory proteins that also promote coronary artery atherosclerosis. This was discovered by infecting cultured human aortic smooth muscle cells with P. gingivalis. Aortic smooth muscle cells were used because they contract the aorta after the pumping of the heart stretches it out. 

After P. gingivalis was injected into the cells, the bacteria released gingipains. Gingipains are enzymes that change the ratio between different angiopoietins (inflammatory proteins) in such a way that inflammation is increased. The pro-inflammatory angiopoietin 2 had its expression increased by the gingipains, whereas the anti-inflammatory angiopoietin 1 had its expression reduced. P gingivalis was found to affect the levels of these proteins independent of tumor necrosis factor (TNF). 

The study is significant because it helps to pinpoint the relationship between periodontitis and heart disease. Further research can help clarify potential targets for treatment of atherosclerosis. 

Practice Pearls: 

Periodontitis and heart disease share a common pathogen, P. gingivitis. 
A study found that P. gingivitis alters gene expression to increase production of the pro-inflammatory protein angiopoietin 2 and decreases presence of the anti-inflammatory protein angiopoietin 1. This results in increased atherosclerosis. 
The study further clarifies the cardiovascular risk of poor oral health and hygiene. 
Paddock C. Scientists uncover bacterial mechanism that links gum disease to heart disease. published in the journal Infection and Immunity. September 14, 2015. 

We recommend 

PERIODONTAL DISEASE AND DIABETES 
Diabetes in control , 2006 
Is Periodontal Disease Influenced by Diabetes Type? 
Diabetes in control , 2014 
Diabetes Linked to Tooth Decay 
Diabetes in control , 2011 
Scientists uncover bacterial mechanism that links gum disease to heart disease 
Catharine Paddock PhD, Medical News Today, 2015 
Periodontitis and heart disease: Researchers connect the molecular dots 
American Society for Microbiology News via MDLinx, 2015 
The Biphasic Virulence Activities of Gingipains: Activation and Inactivation of Host Proteins



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Contact Us
We encourage you to contact us whenever you have an interest or concern about dentistry procedures such as porcelain veneers, dental implants, and tooth whitening in Walnut Creek, Vacaville, Napa, Chandler, Glendale, Martinez, and Phoenix...

Dental Services
... Bonding Cosmetic Contouring Excessive or Uneven Gums Implants Veneers Teeth Whitening Sealants Root Canal Therapy Scaling and Root Planing Flap Surgery Dentures Cosmetic Dentistry Crowns Oral Surgery Six Month Smiles   Initial Oral Examination Your initial oral examination includes a visual examination, charting, periodontal probing, diagnosis and treatment recommendations...

Periodontal Exams
... During your periodontal examination, your dentist will check: For any lumps or abnormal areas in the mouth Whether any of your teeth are missing or loose The color, texture, size and shape of your gums Whether you have fillings, crowns, bridges, dentures or implants How much plaque is on your teeth The depth of the space between your tooth and gum Gingivitis is the first stage of periodontal disease that causes inflammation of the gums...

Missing Teeth
Fixed bridges and implants are often used to replace missing teeth and to correct some kinds of bite problems...

Crowns
... Crowns are also used to attach bridges, cover implants, prevent a cracked tooth from becoming worse, or an existing filling is in jeopardy of becoming loose or dislocated...

Dentures
... An overdenture is a removable denture that fits over a small number of remaining natural teeth or implants...

Implants
Before development of dental implants, dentures were the only alternative to replacing a missing tooth or teeth...

Crowns and Bridges
... Bridges are sometimes referred to as fixed partial dentures, because they are semi-permanent and are bonded to existing teeth or implants...

General Dentistry
...General dentists are highly educated and trained in multiple facets of dentistry, providing a variety of different services for you and your family including: Crowns and bridges Dentures Dental implants Gum disease (Periodontal) treatment Orthodontics Root canal therapy Teeth cleanings Bonding Dental fillings General dentists who do not perform a certain treatment will provide you with a specialist referral...

Tobacco
... Smoking and Implants Recent studies have shown that there is a direct link between oral tissue and bones loss and smoking...

Glossary
... Overdenture - A non-fixed dental appliance applied to a small number of natural teeth or implants...